171031
NR0B1 (AHX, AHC, AHCH, DSS, DAX1, DAX 1, DAX-1, Adrenal hypoplasia congenita, Dosage-sensitive sex reversal, GTD, HHG, Nuclear Hormone Receptor, NROB1, Nuclear Receptor DAX-1, SRXY2, Nuclear Receptor DAX1, Dax-1)
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£735.00
- SKU:
- 171031
- Anwendung:
- IHC-Fr
- Reinheit:
- Purified by immunoaffinity chromatography.
- Lagerbedingungen:
- -20°C
- Hersteller:
- United States Biological
- Host:
- Rabbit
- Immunogen:
- Synthetic peptide corresponding to 20aa from the C-terminus of human NR0B1/DAX1. Species sequence homology: gorilla and gibbon.
- Format:
- Supplied as a liquid in PBS, 0.09% sodium azide.
- Weitere Details:
- DAX-1 (DSS-AHC critical region on the X chromosome, gene 1) is an orphan NRO Knirps-Like nuclear receptor that is involved in adrenal gland and gonad development. DAX-1 has been shown to negatively regulate transcription of the nuclear receptor steroidogenic factor 1 (SF-1). DAX-1 is also involved in the development and differentiation of anterior pituitary cells and in steroidogenesis. In the nucleus, DAX-1 binds to a retinoic acid-responsive element (RARE) and acts as a dominant-negative regulator of retinoic acid receptor-mediated transcription. DAX-1 gene transcription is regulated by Ad4BP/SF-1 (NR5A1) and is suppressed by androgens and the androgen receptor (AR/NR3C4); AR down-regulated DAX-1 gene transcription is mediated by Ad4BP/SF-1 in the presence of the ligand. Recently it has been shown that DAX-1 is required for testis development (Meeks et al. 2003). Mutations in the human DAX-1 gene lead to X-linked adrenal hypoplasia congenita and hypogonadotropic hypogonadism. Recently two isoforms of DAX-1 has been identified. Applications: Suitable for use in Immunohistochemistry. Other applications not tested. Recommended Dilution: Immunohistochemistry (Formalin fixed paraffin embedded): 11ug/ml Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months after receipt. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
- Versandbedingungen:
- Blue Ice