MST1R (RON, C-met-related Tyrosine Kinase, CD136, CDw136, CD136 Antigen, Friend virus susceptibility 2, Fv2, MSP Receptor, P185-Ron, PTK8 Protein Tyrosine Kinase 8, Soluble RON Variant 3, Soluble RON Variant 1, MST1R Variant RON30, Oncogene RON, PTK8, MST1R Variant RON62, Protein-Tyrosine Kinase 8, RON Variant E2E3, Soluble RON Variant 2, Soluble RON Variant 4)

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£735.00

SKU:: 170985
Anwendung:: IHC-Fr
Reinheit:: Purified by immunoaffinity chromatography.
Lagerbedingungen:: -20°C
Hersteller:: United States Biological
Host:: Rabbit
Immunogen:: Synthetic peptide corresponding to 18aa from the N-terminus of human MST1R/Ron. Species sequence homology: gibbon and canine.
Format:: Supplied as a liquid in PBS, 0.09% sodium azide.
Weitere Details:: MST1R/Ron, a HGF Receptor/MET -type protein kinase, mediates the biological activities of macrophage-stimulating protein (MSP), a multifunctional cytokine that regulates cell adhesion, motility, growth, and survival. The protein is a membrane-spanning, disulfide-linked heterodimer, which results from cleavage of a glycosylated precursor into 35kD (alpha) and 150kD (beta) subunits. Ligand binding results in tyrosine phosphorylation of the beta chain. In knockout studies, MST1R/RON (-/-) mice failed to survive past the periimplantation period. The MST1R/RON gene has been mapped to 3p21, a region of frequent deletion or mutation in small cell lung and renal carcinoma, and has been implicated in the progression of several epithelial cancers. Applications: Suitable for use in Immunohistochemistry. Other applications not tested. Recommended Dilution: Immunohistochemistry (Formalin fixed paraffin embedded): 2.5ug/ml Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months after receipt. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

Versandbedingungen:: Blue Ice