CHRM2 (CHRM2, 7TM Receptor, HM2, M2 Muscarinic Receptor, M2-mAChR, Muscarinic Receptor M2, Muscarinic M2 Receptor)

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£709.00

SKU:: 170306
Anwendung:: IHC-Fr
Reinheit:: Purified by immunoaffinity chromatography.
Lagerbedingungen:: -20°C
Hersteller:: United States Biological
Host:: Rabbit
Immunogen:: Synthetic peptide corresponding to 16aa from 3rd cytoplasmic domain of human CHRM2.
Format:: Supplied as a liquid in PBS, 0.09% sodium azide.
Weitere Details:: Muscarinic cholinergic receptor 2, an Acetylcholine Receptor, has been suggested to function as a presynaptic autoreceptor that inhibits acetylcholine release. The M2 receptor has also been suggested to mediate smooth muscle contractility. Alzheimer's disease (AD) involves selective loss of M2 subtype receptors in cortical and hippocampal regions of the human brain. Increase in M2 receptor heterozygosity has been associated with depression in women. Applications: Suitable for use in Immunohistochemistry. Other applications not tested. Recommended Dilution: Immunohistochemistry (Formalin fixed paraffin embedded): 4ug/ml Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months after receipt. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.