168498
Scyth (Bat3, Large Proline-rich Protein BAG6, BAG Family Molecular Chaperone Regulator 6, BCL2-associated Athanogene 6, BAG-6, BAG6, HLA-B-associated Transcript 3, Protein Scythe, Bag6) [KO Validated] (Not for Export EU)
Größe
£908.00
- SKU:
- 168498
- Reinheit:
- Serum
- Lagerbedingungen:
- -20°C
- Hersteller:
- United States Biological
- Host:
- Rabbit
- Immunogen:
- Synthetic peptide corresponding to a region near the C-terminal portion of mouse Scythe/BAT3.
- Format:
- Supplied as a liquid in PBS, pH 7.2, 0.01% sodium azide.
- Weitere Details:
- Scythe protein (also known as BAT3 and HLA-B-associated transcript 3) is an apoptotic regulator that is highly conserved in eukaryotes and contains a ubiquitin-like domain near its N-terminal. It binds Reaper, a potent apoptotic inducer, as well as Hid and Grim. Scythe and Reaper are thought to signal apoptosis, in part through regulating the folding and activity of apoptotic signaling molecules. Scythe regulates apoptosis-inducing factor stability during endoplasmic reticulum stress-induced apoptosis. It interacts with transforming growth factor-b (TGF-b) receptors and enhances TGF-b1-induced type I collagen expression in mesangial cells. With SET1A, Scythe forms a complex with CTCFL/BORIS to modulate H3K4 histone dimethylation and gene expression. Scythe is essential for p300-mediated acetylation of p53. Scythe/BAT3 is identified as a critical regulator of hsp70-2 in spermatogenesis, thereby providing a possible molecular target in idiopathic male infertility. The human Scythe/BAT3 ortholog in rodents is predominantly and developmentally expressed in testis. Applications: Suitable for use in ELISA and Western Blot. Other applications not tested. Recommended Dilution: Western Blot: 1:5000-1:8000 Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months after receipt. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
- Versandbedingungen:
- Blue Ice