167682
MMP-16 (Matrix Metalloproteinase 16/Membrane Type 3 MMP, MT3-MMP)
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£825.00
- SKU:
- 167682
- Anwendung:
- Flow Cytometry
- Reinheit:
- Purified by Protein A or G affinity chromatography.
- Lagerbedingungen:
- -20°C
- Hersteller:
- United States Biological
- Host:
- Mouse
- Immunogen:
- Recombinant protein corresponding to aa32-535 from human MMP-16/MT3-MMP, CHO-derived (UniProt # P51512).
- Klon:
- 782005
- Format:
- Supplied as a lyophilized powder from PBS, pH 7.4, 5% trehalose. Reconstitute with 200ul sterile PBS.
- Weitere Details:
- Matrix metalloproteinases (MMPs) are a family of zinc and calcium dependent endopeptidases with the combined ability to degrade all the components of the extracellular matrix (ECM). MMP16 (MT3MMP) is found in brain, lung, placenta, smooth muscle cells, and malignant tumor tissues including oral melanoma and renal carcinoma (1). MMP16 has been shown to activate proMMP2 and degrade various ECM components including native collagens (2, 3). MMP16 has been proposed to possess the potential to directly enhance the growth and invasiveness of cells in vivo, two critical processes for development and carcinogenesis (4). Structurally, MMP16 consists of the following domains: a pro domain containing the furin cleavage site, a catalytic domain containing the zincbinding site, a hinge region, a hemopexinlike domain, a transmembrane domain, and a cytoplamasic tail (1). The structure of the catalytic domain in complex with a hydroxamate inhibitor has been solved (5). Applications: Suitable for use in Flow Cytometry. Other applications not tested. Recommended Dilution: Flow Cytometry: 2.5ug/10e6cells Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
- Versandbedingungen:
- Blue Ice