TNFSF15, Recombinant, Human, Active (Tumor Necrosis Factor Ligand Superfamily Member 15, TNF Ligand-related Molecule 1, TL1, TL1A, Vascular Endothelial Cell Growth Inhibitor, VEGI, VEGI192A)

Größe

£341.00

SKU:: 149658
Reinheit:: ~98% (SDS-PAGE and HPLC)
Lagerbedingungen:: -20°C
Hersteller:: United States Biological
Format:: Supplied as a lyophilized powder.
Weitere Details:: TL-1A belongs to the TNF superfamily of ligands. It is expressed predominantly in endothelial cells, and to a lesser extent in placenta, lung, kidney, skeletal muscle, pancreas, small intestine and colon. TL-1A inhibits endothelial cell proliferation and angiogenesis, and has been shown to induce NFkB activation, caspase activity, and apoptosis in responding cell lines. TL-1A interacts with TNFRSF25/DR3 receptor, but can also bind to a decoy receptor TNFRSF21/DR6. Recombinant human TL-1A is a 22kD polypeptide of 194aa. Source: Recombinant protein corresponding to human TL-1A, expressed in E.coli. Biological Activity: Determined by its ability to stimulate IFN-gamma production by human PBMC using a concentration range of 10-100ng/ml. Note: Results may vary with PBMC donors. Endotoxin: <0.1ng/ug (1EU/ug) AA Sequence: QLRAQGEASV QFQALKGQEF APSHQQVYAP LRADGDKPRA HLTVVRQTPT QHFKNQFPAL HWEHELGLAF TKNRMNYTNK FLLIPESGDY FIYSQVTFRG MTSECSEIRQ AGRPNKPDSI TVVITKVTDS YPEPTQLLMG TKSVCEVGSN WFQPIYLGAM FSLQEGDKLM VNVSDISLVD YTKEDKTFFG AFLL Storage and Stability: May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.

Versandbedingungen:: Blue Ice