NALP4 (NACHT-, LRR-and PYD-containing Protein 4, NACHT Leucine Rich Repeat and PYD Containing 4, CLR19.5, FLJ32126, Nucleotide Binding Oligomerization Domain Leucine Rich Repeat and Pyrin Domain Containing 4, NLR Family Pyrin Domain Containing 4, NLRP4, PAAD and NACHT Containing Protein 2, PAN2, PYRIN Containing APAF1-like Protein 4, PYPAF4, Ribonuclease Inhibitor 2, RNH2)

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£655.00

SKU:: 146720
Reinheit:: Purified by immunoaffinity chromatography.
Lagerbedingungen:: -20°C
Hersteller:: United States Biological
Host:: Rabbit
Immunogen:: Synthetic peptide corresponding to 13aa from near the center of human NALP4.
Format:: Supplied as a liquid in PBS, 0.02% sodium azide.
Weitere Details:: NALP proteins include the apoptosis regulator APAF1 (apoptotic protease activating factor 1) and mammalian NOD-LRR proteins and are thought to be involved in inflammation and reproduction. NALP4, also known as PYRIN-containing APAF1-like protein 4, has a C-terminal leucine-rich repeat (LRR) region, an N-terminal Pyrin domain (PYD) followed by a NACHT domain, and a NACHT-associated domain. In transfected 293 cells, NALP4 suppressed NF-kB induction by TNF-a and IL-1b, suggesting NALP4 operates at a point of convergence in these two signaling pathways. NALP4 also suppressed NF-kB induction resulting from overexpression of several adapter proteins and protein kinases involved in these pathways, including TRAF2, TRAF6, RIP, and IRAK2, as well as the IKK-a and IKK-b, suggesting that NALP4 is critical in modulating NF-kB activity. Applications: Suitable for use in ELISA and Western Blot. Other applications not tested. Recommended Dilution: Western Blot: 1ug/ml Optimal dilutions to be determined by the researcher. Positive Control: K562 Cell Lysate Storage and Stability: May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months after receipt. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

Versandbedingungen:: Blue Ice