145995
NKIRAS1 (KBRAS1, NF-kappa-B Inhibitor-interacting Ras-like Protein 1, I-kappa-B-interacting Ras-like Protein 1, Kappa B-Ras Protein 1, KappaB-Ras1)
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£655.00
- SKU:
- 145995
- Reinheit:
- Purified by immunoaffinity chromatography.
- Lagerbedingungen:
- -20°C
- Hersteller:
- United States Biological
- Host:
- Rabbit
- Immunogen:
- Synthetic peptide corresponding to 15aa from near the C-terminus of human KappaB ras1.
- Format:
- Supplied as a liquid in PBS, 0.02% sodium azide.
- Weitere Details:
- KappaB ras-1 (kB-ras-1) and kB-ras-2 are two small proteins that similar to Ras-like small GTPases that associate with IkappaB (IkB), an inhibitor of the transcription factor NF-kB. IkB exists in two homologous forms, IkB-a and IkB-B, although IkB-B contains a unique 47aa region within its ankyrin domain. While inactive IkB-a-NF-kB complexes can shuttle in and out of the nucleus, IkB-B-NF-kB complexes are retained exclusively in the cytoplasm. It is suggested that kB-ras proteins preferentially bind to the IkB-B form through this unique insert within the ankyrin region, thus modulating the cellular location of IkB-B and regulating the rate of degradation of IkB-k. This antibody is specific for kB-ras1 and has no cross-reactivity to kB-ras2. Applications: Suitable for use in ELISA, Western Blot and Immunocytochemistry. Other applications not tested. Recommended Dilution: Western Blot: 0.5-2ug/ml Immunocytochemistry: 1ug/ml Optimal dilutions to be determined by the researcher. Positive Control: RAW264.7 Cell Lysate Storage and Stability: May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months after receipt. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
- Versandbedingungen:
- Blue Ice