AK 7 (N-(3-Bromophenyl)-3-[(hexahydro-1H- azepin-1-yl)sulfonyl]benzamide)

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£382.00

SKU:: 145661
Molekulargewicht:: 437.35
Reinheit:: ~98% (HPLC)
Lagerbedingungen:: 4°C
Hersteller:: United States Biological
CAS Number:: 420831-40-9
Format:: Supplied as an off-white solid.
Weitere Details:: Selective SIRT2 inhibitor (IC50 = 15.5um); displays no effect on SIRT1 or SIRT3. Decreases neuronal cholesterol levels; improves motor function and ameliorates brain atrophy in a mouse model of Huntington's disease. Brain penetrant. Sequence: C19H21BrN2O3S Solubility: DMSO (~100mM) Molecular Weight: ~437.35 Storage and Stability: Lyophilized powder may be stored at -20°C. Stable for 12 months at -20°C. Reconstitute with sterile buffer or ddH2O. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Reconstituted product is stable for 6 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.