PLK2 (PLK-2, SNK, hPlk2, hSNK, Polo-like kinase 2, Serum-inducible kinase, Polo-like kinase 2 (Drosophila), Serine/threonine-protein kinase SNK, Proprotein convertase, subtitisin/kexin-type, 9)

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£620.00

SKU:: 145066
Reinheit:: Purified by immunoaffinity chromatography.
Lagerbedingungen:: 4°C/-20°C
Hersteller:: United States Biological
Host:: Rabbit
Immunogen:: A synthetic peptide corresponding to a sequence at the C-terminal of human PLK2, different from the related mouse sequence by one amino acid, and from the related rat sequence by two amino acids.
Format:: Supplied as a lyophilized powder from PBS, 5% BSA, 0.05% Thimerosal, 0.05% sodium azide. Reconstitutie with 200ul sterile ddH2O.
Weitere Details:: Polo-like kinase2, also known as SNK is an enzyme that in humans is encoded by the PLK2 gene. PLK2 is a member of the 'polo' family of serine/threonine protein kinases that have a role in normal cell division. The International Radiation Hybrid Mapping Consortium mapped the SNK gene to chromosome 5. SNK involved in synaptic plasticity, centriole duplication and G1/S phase transition. This gene plays a key role in synaptic plasticity and memory by regulating the Ras and Rap protein signaling: required for overactivity-dependent spine remodeling by phosphorylating the Ras activator RASGRF1 and the Rap inhibitor SIPA1L1 leading to their degradation by the proteasome. UniProt Number: Q9NYY3 Gene ID: PLK2 Applications: Suitable for use in Western Blot, Immunohistochemistry (Paraffin) and Immunocytochemistry. Recommended Dilution: Optimal dilutions to be determined by the researcher. Storage and Stability: Lyophilized and reconstituted products are stable for 12 months after receipt at -20°C. Reconstitute with sterile ddH2O. Aliquot to avoid repeated freezing and thawing. Store at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.

Versandbedingungen:: Blue Ice