145022
p27Kip1 (KIP1, MEN4, CDKN4, MEN1B, P27KIP1, Cyclin-dependent kinase inhibitor p27)
Größe
£620.00
- SKU:
- 145022
- Lagerbedingungen:
- 4°C/-20°C
- Hersteller:
- United States Biological
- Host:
- Mouse
- Immunogen:
- Recombinant rodent p27Kip1 protein.
- Klon:
- IMD-27
- Format:
- Ascites, supplied as a lyophilized powder. Reconstitution: 1.2% sodium acetate or neutral PBS. If 1ml of PBS is used, the antibody concentration will be 100ug/ml.
- Weitere Details:
- P27(kip1), also known as cyclin dependent kinase inhibitor 1B(CDKN1B), is a major target of AFX-like forkhead proteins. CDKN1B (p27) belongs to the Cip/Kip family and functions as an important cell cycle gatekeeper.Phosphorylation leads to the ubiquitination and degradation of CDKN1B. P27(kip1) mapped to 12p13. An increase in p27 causes proliferating cells to exit from the cell cycle, and a decrease in p27 is necessary for quiescent cells to resume division. Abnormally low amounts of p27 are associated with pathological states of excessive cell proliferation, especially cancers. Overexpression of p27Kip1 lengthens the G1 phase in a mouse model that targets inducible gene expression to central nervous system progenitor cells. UniProt Number: Human(P46527), Mouse(P46414), Rat(O08769) Gene ID: CDKN1B Applications: Suitable for use in Western Blot and Immunocytochemistry. Recommended Dilution: Optimal dilutions to be determined by the researcher. Storage and Handling: Store at -20˚C for one year. After reconstitution, store at 4˚C for one month. Can also be aliquoted and stored frozen at -20˚C for long term. Avoid repeated freezing and thawing. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
- Versandbedingungen:
- Blue Ice