NUP98 (Nuclear pore complex protein Nup98 Alternative name(s): 98kD nucleoporin Nucleoporin Nup982.Nuclear pore complex protein Nup96, Nup96)

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£722.00

SKU:: 143219
Reinheit:: Purified by immunoaffinity chromatography.
Lagerbedingungen:: -20°C
Hersteller:: United States Biological
Host:: Mouse
Immunogen:: Purified recombinant human NUP98 protein fragments expressed in E. coli.
Klon:: 13k92
Format:: Supplied as a liquid in 0.1M Tris-Glycine, pH 7.4, 150mM NaCl, 0.2% sodium azide, 50% glycerol.
Weitere Details:: Signal-mediated nuclear import and export proceed through the nuclear pore complex (NPC), which is comprised of ~50 unique proteins collectively known as nucleoporins. The 98kD nucleoporin is generated through a biogenesis pathway that involves synthesis and proteolytic cleavage of a 186kD precursor protein. This cleavage results in the 98kD nucleoporin as well as a 96kD nucleoporin, both of which are localized to the nucleoplasmic side of the NPC. Rat studies show that the 98kD nucleoporin functions as one of several docking site nucleoporins of transport substrates. The human gene has been shown to fuse to several genes following chromosome translocations in acute myelogenous leukemia (AML) and T-cell acute lymphocytic leukemia (T-ALL). This gene is one of several genes located in the imprinted gene domain of 11p15. 5, an important tumor-suppressor gene region. Alterations in this region have been associated with the Beckwith-Wiedemann syndrome, Wilms tumor, rhabdomyosarcoma, adrenocortical carcinoma, and lung, ovarian, and breast cancer. Alternative splicing of this gene results in several transcript variants; however, not all variants have been fully described. Applications: Suitable for use in Western Blot and Immunoprecipitation. Other applications not tested. Recommended Dilution: Western Blot: 1:1000 Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

Versandbedingungen:: Blue Ice