137251
Abl Kinase, Active, Recombinant, Human, His-Tag (ABL, Tyrosine-protein Kinase ABL1, Abelson Murine Leukemia Viral Oncogene Homolog 1, c-Abl, Proto-oncogene c-Abl, p150, ABL1, JTK7)
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£881.00
- SKU:
- 137251
- Molekulargewicht:
- 33
- Reinheit:
- Purified (~75%)
- Lagerbedingungen:
- -70°C
- Hersteller:
- United States Biological
- Format:
- Supplied as a liquid in 25mM Tris-HCl, pH 8.0, 100mM sodium chloride, 0.05% Tween 20, 20% glycerol, 3mM DTT.
- Weitere Details:
- The c-ABL proto-oncogene encodes a protein tyrosine kinase that is located in the cytoplasm and nucleus. In chronic myelogenous leukemia and in a subset of acute lymphoblastic leukemias, the c-ABL proto- oncogene undergoes a chromosomal translocation producing a novel rearranged chromosome (the Philadelphia chromosome) as a result of the fustion of c-ABL sequences from chromosome 9 to the Bcr gene on chromosome 22. The molecular consequence of this translocation is the generation of a chimeric Bcr/ABL mRNA encoding activated ABL protein tyrosine kinase. Source: Recombinant corresponding to aa248-531 from human Abelson murine leukemia viral oncogene homolog 1, fused to His-tag at N-terminal, expressed in a Baculovirus-infected Sf9 cell expression system. Molecular Weight: ~33kD Applications: Suitable for use in the study of enzyme kinetics, screening inhibitors, and selectivity profiling. Other applications not tested. Recommended Dilution: Optimal dilutions to be determined by the researcher. Specific Activity: ~288pmol/min/ug Storage and Stability: Aliquot to avoid repeated freezing and thawing and store at -70°C. Aliquots are stable for 6 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
- Versandbedingungen:
- Dry Ice