136937
NMDA Receptor NR1, Splice Variant N1 (N-methyl-D-aspartate Receptor Subunit NR1, NMD-R1, NMDAR1, Nmdar, NR1, Glutamate [NMDA] Receptor Subunit zeta-1, Grin1, GluRdelta1, GluRzeta1, Glurz1, M100174, Rgsc174) (Not for Export EU)
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£927.00
- SKU:
- 136937
- Reinheit:
- Serum
- Lagerbedingungen:
- -20°C
- Hersteller:
- United States Biological
- Host:
- Rabbit
- Immunogen:
- Peptide corresponding to N1 splice variant of NMDA Receptor 1.
- Format:
- Supplied as a lyophilized powder from 5mM ammonium bicarbonate. Reconstitute with 50ul PBS, pH 7.4.
- Weitere Details:
- N-methyl-D-aspartate receptor (NMDAR) forms a heterodimer of at least one NR1 and one NR2A-D subunit. Multiple receptor isoforms with distinct brain distributions and functional properties arise by selective splicing of the NR1 transcripts and differential expression of the NR2 subunits. NR1 subunits bind the co-agonist glycine and NR2 subunits bind the neurotransmitter glutamate. NMDA receptors are among the most studied receptors in neuroscience because they are involved in neuronal cell development and plasticity, a cellular correlate for learning. NMDA receptors are also implicated in several disorders of the central nervous system including epilepsy and ischemic neuronal cell death. NMDA receptors also appear to be a target for ethanol at physiological concentrations and therefore may play a significant role in alcoholism. Applications: Suitable for use in Immunohistochemistry and Western Blot. Other applications not tested. Recommended Dilution: Immunohistochemistry: 1:1000 Western Blot: 1:1000-1:2000, ~100kD band in rat hippocampal homogenate Optimal dilutions to be determined by the researcher. Storage and Stability: Lyophilized powder may be stored at -20°C. Stable for 12 months at -20°C after receipt. Reconstitute with sterile PBS. Aliquot to avoid repeated freezing and thawing. Store at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
- Versandbedingungen:
- Blue Ice