130842
PAK1IP1 (p21-activated Protein Kinase-interacting Protein 1, PAK/PLC-interacting Protein 1, hPIP1, PAK1-interacting Protein 1, WD Repeat-containing Protein 84, PIP1, WDR84)
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£685.00
- SKU:
- 130842
- Reinheit:
- Purified by Protein A affinity chromatography.
- Lagerbedingungen:
- -20°C
- Hersteller:
- United States Biological
- Host:
- Mouse
- Immunogen:
- Full length human PAK1IP1, aa1-393 (AAH10907).
- Format:
- Supplied as a liquid in PBS, pH 7.2.
- Weitere Details:
- The family of p21-activated protein kinases (PAKs) is composed of serine-threonine kinases whose activity is regulated by the GTPases, Rac and Cdc42. PAKs have been implicated in the regulation of mitogen-activated protein cascades, cellular morphological and cytoskeletal changes, neurite outgrowth, and cell apoptosis. A novel human PAK-interacting protein, hPIP1, interacts with PAK1 and inhibits the Cdc42/Rac-stimulated kinase activity suggesting that hPIP1 is a negative regulator of PAK and PAK signaling pathways. Applications: Suitable for use in Immunofluorescence and Western Blot. Other applications not tested. Recommended Dilution: Immunofluorescence: 10ug/ml Optimal dilutions to be determined by the researcher. AA Sequence: MELVAGCYEQVLFGFAVHPEPEACGDHEQWTLVADFTHHAHTASLSAVAVNSRFVVTGSKDETIHIYDMKKKIEHGALVHHSGTITCLKFYGNRHLISGAEDGLICIWDAKKWECLKSIKAHKGQVTFLSIHPSGKLALSVGTDKTLRTWNLVEGRSAFIKNIKQNAHIVEWSPRGEQYVVIIQNKIDIYQLDTASISGTVTNEKRISSVKFLSESVLAVAGDEEVIRFFDCDSLVCLCEFKAHENRVKDMFSFEIPEHHVIVSASSDGFIKMWKLEQDKKVPPSLLCEINTNARLTCLGVWLDKVADMKESLPPAAEPSPVSKEQSKIGKKEPGDTVHKEEKRSKPNTKKRGLTGDSKKATKESGLISTKKRKMVEMLEKKRKKKKIKTMQ* Storage and Stability: May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months after receipt. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
- Versandbedingungen:
- Blue Ice