124798
CDK9 (Cyclin-dependent Kinase 9, C-2K, Cell Division Cycle 2-like Protein Kinase 4, Cell Division Protein Kinase 9, Serine/Threonine-protein Kinase PITALRE, CDC2L4)
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£685.00
- SKU:
- 124798
- Reinheit:
- Purified by Protein A affinity chromatography.
- Lagerbedingungen:
- -20°C
- Hersteller:
- United States Biological
- Host:
- Mouse
- Immunogen:
- Partial recombinant corresponding to aa271-372 from human CDK9 (AAH01968) with GST tag. MW of the GST tag alone is 26kD.
- Klon:
- 2D7
- Format:
- Supplied as a liquid in PBS, pH 7.2.
- Weitere Details:
- CDK9 (cyclin-dependent kinase 9, serine/threonine-protein kinase PITALRE) is a member of the cell division cycle 2 (CDC2) family of kinases that play a pivotal role in the regulation of the eukaryotic cell cycle. CDK9 expression is ubiquitous, but its expression levels are different in various human tissues. CDK9 is localized primarily to the nucleus. At pathophysiological levels, CDK9 activity suppresses many genes for mitochondrial proteins including master regulators of mitochondrial function (peroxisome proliferator-activated receptor gamma coactivator 1 (PGC-1), nuclear respiratory factor-1). Chronic activation of CDK9 causes not only cardiomyocyte enlargement but also defective mitochondrial function. The cyclinT/CDK9 complex, also called positive transcription elongation factor b (p-TEFb), phosphorylates the C-terminal domain of the large subunit of RNA polymerase II, stimulating transcription elongation and pre-mRNA processing. Applications: Suitable for use in ELISA and Western Blot. Other applications not tested. Recommended Dilution: Optimal dilutions to be determined by the researcher. AA Sequence: QKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF Storage and Stability: May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
- Versandbedingungen:
- Blue Ice