052749X

Kv3.1b (Potassium Voltage-Gated Channel Subfamily C Member 1, Kcnc1, Voltage-Gated Potassium Channel Subunit Kv3.1, KV4, NGK2, RAW2, Voltage-Gated Potassium Channel Subunit Kv4)

Größe

£806.00

SKU:: 052749X
Reinheit:: Purified by Protein A affinity chromatography from hybridoma culture.
Lagerbedingungen:: -20°C
Hersteller:: United States Biological
Host:: Mouse
Immunogen:: Fusion protein corresponding to aa437-585 (cytoplasmic C-terminus) of rat Kv3.1b, expressed in E. coli.
Klon:: N16B/8
Format:: Supplied as a liquid in PBS. No preservative added. For antibody with azide, see 052749.
Weitere Details:: Potassium voltage-gated channel subfamily C member 1, or Kv3.1b is encoded by the gene KCNC1. Kv3.1 is a member of the Shaw subfamily of voltage gated potassium channels. Kv3.1b is expressed in many parts of the brain including the cerebellum, globus pallidus, subthalamic nucleus, substantia nigra, cortical and hippocampal in neurons at presynaptic membranes. It is also expressed in retinal ganglion cells and muscle and testis tissues. It is an integral membrane protein that mediates the voltage-dependent potassium ion permeability of excitable membranes. Its function is important in repolarization of action potentials and is expressed in neurons that execute repetitive high frequency firing. Alterations in expression are associated with certain types of epilepsy, spinocerebellar ataxia, unverricht-lundborg syndrome and demyelinating diseases. Applications: Suitable for use in ELISA, Immunoprecipitation, Immunocytochemistry, Western Blot and Immunohistochemistry. Other applications not tested. Recommended Dilutions: Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months after receipt. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

Versandbedingungen:: Blue Ice