052652
Megakaryocyte-Erythroid Progenitor
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£793.00
- SKU:
- 052652
- Reinheit:
- Purified
- Lagerbedingungen:
- -20°C
- Hersteller:
- United States Biological
- Host:
- Mouse
- Immunogen:
- Human megakaryocytic CMK cells.
- Klon:
- BAH-1
- Format:
- Supplied as a liquid in PBS. No preservative added.
- Weitere Details:
- Megakaryocyte/erythroid progenitors (MEPs) are bipotent cells that undergo a fate decision to become either megakaryocytes (Mk) or erythroid (E) cells. Proliferation and differentiation of MEP is shown to be regulated by the presence of thrombopoietin. 052652 recognizes c-Mpl, the thrombopoietin receptor with high affinity (Kd = 0.61nM) and exhibits agonistic activity in stimulating megakaryocytopoiesis and production of mature GpIIb/IIIa-expressing megakaryocytes. However, it does not recognize glycoproteins Ib or IIb/IIIa. This clone is useful in distinguishing subsets of hematopoietic stem cells and myeloid progenitors. Applications: Suitable for use in ELISA, Flow Cytometry, Western Blot, Inhibition Assays, and Immunoprecipitation. Other applications not tested. Recommended Dilution: Western Blot: 1:1000 detected an 84kD c-Mpl protein that is expressed on megakaryocytic cells (DAMI). Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months after receipt. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
- Versandbedingungen:
- Blue Ice