Mertansine (DM1, Drug Maytansinoid 1, Emtansine) (Biotin)

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£832.00

SKU:: 052415
Reinheit:: Purified by Protein A affinity chromatography.
Lagerbedingungen:: -20°C
Hersteller:: United States Biological
Host:: Rabbit
Immunogen:: Mertansine-KLH conjugate
Format:: Supplied as a liquid in PBS, pH 7.2, 0.02% sodium azide, 50% glycerol. Labeled with Biotin.
Weitere Details:: Mertansine is a synthetic maytansinoid antimitotic agent. It disrupts mitotic spindle formation and induces cell cycle arrest and cell death in cancer cells. Mertansine has commonly been used as a payload in antibody-drug conjugates (ADCs) to selectively target cancer cells in vitro and in vivo. Formulations containing mertansine conjugated to ado-trastuzumab have been used in the treatment of HER2+ breast cancer. Applications: Suitable for use in ELISA and Western Blot. Other applications not tested. Recommended Dilution: Western Blot: 1:200 ELISA: 1:200 Optimal dilutions to be determined by the researcher. Storage and Stability: Store product at 4°C if to be used immediately within two weeks. For long-term storage, aliquot to avoid repeated freezing and thawing and store at -20°C. Aliquots are stable at -20°C for 12 months after receipt. Dilute required amount only prior to immediate use. Further dilutions can be made in assay buffer. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.