052204
CCL22 (C-C Motif Chemokine 22, MDC, Macrophage Derived Chemokine, Small-Inducible Cytokine A22)
Größe
£767.00
- SKU:
- 052204
- Reinheit:
- Purified by Protein G affinity chromatography.
- Lagerbedingungen:
- -20°C
- Hersteller:
- United States Biological
- Host:
- Mouse
- Immunogen:
- Recombinant protein fragment of human CCL22 corresponding to 67aa in the mature protein.
- Klon:
- 6F5.7
- Format:
- Supplied as a liquid in PBS, 0.05% sodium azide
- Weitere Details:
- C-C motif chemokine 22 (UniProt: O00626; also known as CC chemokine STCP-1, MDC(1-69), Macrophage-derived chemokine, Small-inducible cytokine A22, Stimulated T-cell chemotactic protein 1, CCL22) is encoded by the CCL22 (also known as MDC, SCYA22, A-152E5.1) gene (Gene ID: 6367) in human. MDC/CCL22 is a member of the intercrine beta family that plays a role in the trafficking of activated/effector T-lymphocytes to inflammatory sites and other aspects of activated T-lymphocyte physiology. It is highly expressed in macrophage and in monocyte-derived dendritic cells, and thymus. It is reported to be chemotactic for monocytes, dendritic cells, and natural killer cells. It displays mild chemoattractant activity for primary activated T-lymphocytes but is a potent chemoattractant for chronically activated T-lymphocytes. Its signaling activity is achieved through the C-C chemokine receptor type 4 (CCR4). It acts as a mediator of lung inflammation after hemorrhage and resuscitation. MDC/CCL22 is synthesized with a signal peptide (aa1-24) that is subsequently cleaved off. It can be proteolytically cleaved into three processed forms that are known as MDC (3-69); MDC (5-69); and MDC (7-69) (numbered without the signal peptide). Applications: Suitable for use in Immunohistochemistry and Western Blot. Other applications have not been tested. Recommended Dilutions: Immunohistochemistry (paraffin): 1:50 detected CCL22/MDC in human skin and human small intestine tissue sections using heat-induced epitope retrieval (HIER). Western Blot: 1:1000 dilution detected human recombinant MDC-CCL22 protein. Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months after receipt. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
- Versandbedingungen:
- Blue Ice