048728
Glucocorticoid Receptor (GR, Nuclear Receptor Subfamily 3 Group C Member 1) (Not for Export EU)
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£735.00
- SKU:
- 048728
- Anwendung:
- WB
- Reinheit:
- Serum
- Lagerbedingungen:
- -20°C
- Hersteller:
- United States Biological
- Host:
- Rabbit
- Immunogen:
- KLH-conjugated linear peptide corresponding to a sequence from the modulating region of human glucocorticoid receptor. Species Sequence Homology: canine, feline, primate, equine and bovine
- Format:
- Supplied as a liquid, 0.05% sodium azide.
- Weitere Details:
- Glucocorticoid receptor (UniProt P04150; also known as GR, Nuclear receptor subfamily 3 group C member 1) is encoded by the NR3C1 (also known as GCCR, GCR, GCRST, GRL) gene (Gene ID 2908) in human. Glucocorticoid receptor is widely expressed in almost all cell types and regulates genes controlling development, metabolism, and immune response upon binding glucocorticoids. Hormone-bound GR translocates from the cytoplasm to the nucleus where it regulates gene transcriptions by binding to glucocorticoid response elements (GREs) or by interacting with various transcription factors. Alternatively, hormone-bound GR can repress gene transcriptions by blocking the nuclear translocation of transcription factors. GR is composed of a modulating domain and a DNA-binding domain at its N-terminal, and a ligand-binding domain at the C-terminal. Applications: Suitable for use in Western Blot. Other applications not tested. Recommended Dilutions: Western Blot: 1:5000 detected glucocorticoid receptor in 10ug of HeLa cell lysate. Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months after receipt. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
- Versandbedingungen:
- Blue Ice