TRAIL-R2, Fc:Human, Recombinant, Human (DR5, TNFRSF 10B, CD262, Tumor Necrosis Factor Receptor Superfamily Member 10B, TRAIL Receptor 2)

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£457.00

SKU:: 045361
Molekulargewicht:: 50
Reinheit:: ≥95% (SDS-PAGE). Endotoxin: <0.01EU/ug (LAL test; Lonza)
Lagerbedingungen:: -20°C
Hersteller:: United States Biological
Format:: Supplied as a lyophilized powder in PBS. Reconstitute with 50ul sterile ddH2O.
Weitere Details:: TRAIL-R2 (DR5; CD262) is a receptor for the cytotoxic ligand TRAIL. The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. Promotes the activation of NF-kappaB. Binds to human and mouse TRAIL. Sequence: The extracellular domain, aa52-212, of human TRAIL-R2, fused to the Fc portion of human IgG1, expressed in HEK 293 cells. Molecular Weight: ~50kD (SDS-PAGE) Biological Activity: Blocks human or mouse TRAIL activity in a concentration of 1-10ug/ml. Storage and Stability: Lyophilized and reconstituted products are stable for 12 months after receipt at -20°C. Reconstitute with sterile ddH2O. Aliquot to avoid repeated freezing and thawing. Store at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.