TRAIL-R1 (TRAIL Receptor 1, DR4, APO2, TNFRSF10A, CD261) (FITC)

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£576.00

SKU:: 045349
Reinheit:: Purified by Protein G affinity chromatography from concentrated hybridoma tissue culture supernatant.
Lagerbedingungen:: -20°C
Hersteller:: United States Biological
Host:: Mouse
Immunogen:: Recombinant protein corresponding to human TRAIL-R1 (DR4).
Klon:: HS101
Format:: Supplied as a liquid in PBS, 0.02% sodium azide. Labeled with Fluorescein isothiocyanate (FITC).
Weitere Details:: TRAIL-R1 is a receptor for the cytotoxic ligand TRAIL. The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. Promotes the activation of NF-kappaB. Applications: Suitable for use in Immunocytochemistry and Flow Cytometry. Other applications not tested. Recommended Dilution: Optimal dilutions to be determined by researcher. Storage and Stability: Store product at 4°C if to be used immediately within two weeks. For long-term storage, aliquot to avoid repeated freezing and thawing and store at -20°C. Aliquots are stable at -20°C for 12 months after receipt. Dilute required amount only prior to immediate use. Further dilutions can be made in assay buffer. Caution: FITC conjugates are sensitive to light. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.