IL-6, Recombinant, Mouse,Fc (Interleukin-6, B Cell Hybridoma Growth Factor, Interleukin HP-1)

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£416.00

SKU:: 044950
Reinheit:: >95% (SDS-PAGE)
Lagerbedingungen:: 4°C/-20°C
Hersteller:: United States Biological
Format:: Supplied as a lyophilized powder from a 0.2um filtered solution in PBS pH 7.2.
Weitere Details:: Interleukin 6 (IL-6) is a pleiotropic alpha-helical cytokine that plays important roles in acute phase reactions, inflammation, hematopoiesis, bone metabolism and cancer progression. IL-6 activity is essential for the transition from acute inflammation to either acquired immunity or chronic inflammatory disease. It is secreted by multiple cell types as a 22kD-28kD phosphorylated and variably glycosylated molecule. IL-6 induces signaling through a cell surface heterodimeric receptor complex composed of a ligand binding subunit (IL-6R) and a signal transducing subunit (gp130). IL-6 is a key factor for the growth of plasma cells. Biological Activity: Promotes growth of hybridoma/plasma cells at concentration <0.1ng /ml. Sequence: The extracellular domain of mouse IL-6 (aa 25-211) is fused at the C-terminus to the Fc portion of human IgG2. Storage and Stability: Short-term Storage: +4°C Long-term Storage: -20°C Stable for at least 1 year after receipt when stored at -20°C. Working aliquots are stable for up to 3 months when stored at -20°C.