IL-36beta, Recombinant, Human (Interleukin-36beta, Interleukin-1 Family Member 8, IL-1F8)

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£434.00

SKU:: 044939
Molekulargewicht:: 15
Reinheit:: ≥95% (SDS-PAGE). Endotoxin: <0.01EU/ug (LAL test; Lonza)
Lagerbedingungen:: -20°C
Hersteller:: United States Biological
Format:: Supplied as a lyophilized powder in PBS, 0.5% Trehalose. Reconstitute with 100ul sterile ddH2O.
Weitere Details:: IL-36alpha (IL-1F6), IL-36beta (IL-1F8) and IL-36gamma (IL-1F9) bind to IL-36R (IL-1Rrp2) and IL-1RAcP, activating similar intracellular signals as IL-1. IL-36Ra inhibits the production of proinflammatory cytokines, including IL-12, IL-1beta, IL-6, TNF-alpha and IL-23 induced by IL-36 in BMDC and CD4 T cells. Skin and dendritic cells are targets of the IL-36 interleukins leading to a Th1 response. These cytokines may represent potential targets for immune-mediated inflammatory conditions or, alternatively, could be used as adjuvants in vaccination. Sequence: Human IL-36beta, Arg5-Glu157, (isoform 2), untagged, expressed in E. coli. Molecular Weight: ~15kD (SDS-PAGE) Storage and Stability: Lyophilized powder may be stored at -20°C. Stable for 12 months after receipt at -20°C. Reconstitute with sterile ddH2O. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Reconstituted product is stable for 6 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.