GITRL, Soluble, Recombinant, Mouse (Glucocorticoid-induced TNF Receptor Ligand, AITRL, Activation-inducible TNF-related Ligand, TNFSF18)

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£544.00

SKU:: 044856
Molekulargewicht:: 22
Reinheit:: ≥90% (SDS-PAGE)
Lagerbedingungen:: 4°C/-20°C
Hersteller:: United States Biological
Format:: Supplied as a liquid from a 0.2um-filtered solution in 10mM glycine, pH 10.0.
Weitere Details:: GITRL (Glucocorticoid-induced TNF receptor ligand) is expressed on dendritic cells (DC), monocytes, macrophages, B cells, activated T cells, endothelial cells, osteoclasts and various healthy non-lymphoid tissues (e.g. testis). GITRL is constitutively expressed and released as soluble form by solid tumors and various hematopoietic malignancies. GITRL causes differentiation of osteoclasts, activation of macrophages, but also alteration of carcinoma and leukemia cells and influences apoptosis. Binding to GITR is important in regulating T cell proliferation and TCR-mediated apoptosis. GITRL is implicated in development of autoimmune diseases and in the immune response against infectious pathogens and tumors. Biological Activity: Induces GITR-mediated NF-kappaB activation in HEK 293 cells. Sequence: The extracellular domain of mouse GITRL (aa 45-173) is fused at the N-terminus to a FLAG®-tag. Endotoxin: <0.1EU/ug (LAL test; Lonza). Storage and Stability: Short-term Storage: +4°C Long-term Storage: -20°C Working aliquots are stable for up to 3 months when stored at -20°C.