RGL4, NT (RGL4, RGR, Ral-GDS-related protein, Ral guanine nucleotide dissociation stimulator-like 4)

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£696.00

SKU:: 040997
Reinheit:: Purified by Protein A affinity chromatography.
Lagerbedingungen:: -20°C
Hersteller:: United States Biological
Host:: Rabbit
Immunogen:: RGL4 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 97-125 amino acids from the N-terminal region of human RGL4.
Format:: Supplied as a liquid in PBS, pH 7.2, 0.09% sodium azide.
Weitere Details:: Ral GDS (Ral guanine nucleotide dissociation stimulator) is a guanine nucleotide exchange factor (GEF) that activates Ral and is implicated in oncogenic Ras-induced cell transformation. RGL4 (ral guanine nucleotide dissociation stimulator-like 4), also known as Rgr, is a 473 amino acid protein that localizes to the cytoplasmic vesicle of cells. Belonging to the GEF family of proteins, RGL4 induces phosphorylation of ERKs, p38 and JNK kinases, and it increases the levels of GTP bound forms of Ral and Ras. Ras activation is crucial for the transforming activity of RGL4. Due to its similarity to Ral GDS, RGL4 may be implicated in carcinogenesis. Applications: Suitable for use in Western Blot, ELISA Recommended Dilution: ELISA: 1:1,000 Western Blot: 1:100-500 Storage and Stability: May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.