GAD2 (GAD2, GAD65, Glutamate decarboxylase 2, 65kD glutamic acid decarboxylase, Glutamate decarboxylase 65kD isoform)

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£672.00

SKU:: 030980
Anwendung:: WB
Reinheit:: Purified by ammonium sulfate precipitation.
Lagerbedingungen:: -20°C
Hersteller:: United States Biological
Host:: Mouse
Immunogen:: Recombinant His-tagged protein corresponding to a fragment of GAD2. (Q05329, NP_000809.1)
Klon:: 458CT17.2.4
Format:: Supplied as a liquid in PBS, 0.09% sodium azide.
Weitere Details:: This gene encodes one of several forms of glutamic acid decarboxylase, identified as a major autoantigen in insulin-dependent diabetes. The enzyme encoded is responsible for catalyzing the production of gamma-aminobutyric acid (GABA) from L-glutamic acid. A pathogenic role for this enzyme has been identified in the human pancreas since it has been identified as an autoantibody and an autoreactive T cell target in insulin-dependent diabetes. This gene may also play a role in the stiff man syndrome. Alternative splicing results in multiple transcript variants that encode the same protein. Applications: Suitable for use in Western Blot. Other applications not tested. Recommended Dilutions: Western Blot: 1:100-1:250 Optimal dilutions to be determined by the researcher. Positive Control: Mouse or rat brain tissue lysates. Storage and Stability: May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.