Rho Kinase Inhibitor (H-1152, H-1152P, (S)-(+)-2-Methyl-1-[(4-methyl-5-isoquinolinyl)sulfonyl]homopiperazine, 2HCl, ROCK Inhibitor)

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SKU:: 029603
Molekulargewicht:: 392.3
Reinheit:: ≥95% (HPLC)
Lagerbedingungen:: 4°C
Hersteller:: United States Biological
CAS Number:: 872543-07-6
Format:: Supplied as a white solid.
Weitere Details:: A cell-permeable isoquinolinesulfonamide compound that acts as a highly specific, reversible, potent, and ATP-competitive inhibitor of G-protein Rho-associated kinase (ROCK; Ki=1.6nM). Inhibits other serine/threonine kinases only at higher concentrations (Ki=630nM for PKA, 9.27 uM for PKC, and 10.1uM for MLCK). Shown to selectively block lysophosphatidic acid-induced, but not PDBu-induced, phosphorylation of myristoylated alanine-rich C kinase substrate (MARCKS) in NT-2 cells (IC50=2.5uM). Reported to be a more potent and selective inhibitor than Y-27632. Synonyms: H-1152, H-1152P, (S)-(+)-2-Methyl-1-[(4-methyl-5-isoquinolinyl)sulfonyl]homopiperazine, 2HCl, ROCK Inhibitor, Dimethylfasudil (diMF, H-1152P) CAS No: 872543-07-6 Molecular Formula: C₁₆H₂₁N₃O₂S • 2HCl Molecular Weight: 392.3 Solubility: H2O (5mg/ml) or Methanol (5mg/ml) Form: Supplied as a white solid. Primary Target: ROCK Purity: ≥95% (HPLC) Appearance: Supplied as a white solid. Storage and Stability: Store at -20°C under inert atmosphere. Caution: Light-sensitive. For maximum recovery of product, centrifuge the original vial prior to removing the cap.