AMPK Inhibitor, Compound C

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£417.00

SKU:: 029416
Molekulargewicht:: 399.5
Lagerbedingungen:: 4°C
Hersteller:: United States Biological
CAS Number:: 866405-64-3
Weitere Details:: A cell-permeable pyrrazolopyrimidine compound that inhibits against KDR/VEGFR2, ALK2/BMPR-I, AMPK kinase activity (IC50=25.1, 148, and 234.6 nM, respectively), while exhibiting much reduced or little effect toward ALK5/TGFbR-I, ZAPK, Syk, PKCth, PKA, or JAK3. Shown to block both BMP pathway-dependent dorsoventral development (EC100=2.5uM) and VEGF signaling-dependent intersomitic vessel formation (EC50=5uM) in zebrafish embryo in vivo. Commonly used in combination with AMPK activators AICAR and/or Metformin for studying AMPK-dependent cellular events in vitro and physiological responses in animals in vivo. Synonyms: 6-[4-(2-Piperidin-1-yl-ethoxy)-phenyl)]-3-pyridin-4-yl-pyrrazolo[1,5-a]-pyrimidine, Dorsomorphin, AMPK Inhibitor I, BMP Inhibitor I CAS No: 866405-64-3 Molecular Formula: C₂₄H₂₅N₅O Molecular Weight: 399.5 Purity: ≥95% (HPLC) Appearance: Light yellow solid Solubility: DMSO (4mg/ml), 2% HCl (10mg/ml), 2% Acetic Acid (10mg/ml), or Methanol (3mg/ml) Storage and Stability: May be stored at 4°C. For long-term storage, aliquot and store at 4°C. Do not freeze. Aliquots are stable for 6 months after receipt. For maximum recovery of product, centrifuge the original vial prior to removing the cap. Further dilutions can be made in assay buffer.