4-Methylumbelliferyl α-L-Idopyranosiduronic Acid 2-Sulfate Disodium Salt

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£761.00

SKU:: 017551
Molekulargewicht:: 476.32
Lagerbedingungen:: -20°C
Hersteller:: United States Biological
CAS Number:: 1045020-74-3
Weitere Details:: 4MU-α-L-iduronide-2-sulfate is a fluorogenic substrate for iduronate-2-sulphatase (IDS), used in a 2-step assay coupled with α-L-iduronidase. The assay is used in biochemical testing for Hunter syndrome (mucopolysaccharidosis II/MPS II). In a first step, iduronidate-2-sulfatase from biological samples cleaves the sulfate group from 4MU-α-L-iduronide-2-sulfate. In a second step, exogeneous α-L-iduronidase which cleaves the 4-MU moiety is added to the reaction, resulting in release of a fluorescent signal (Ex 360nm/Em 455nm). The reaction is stopped by the addition of sodium carbonate. Synonyms: 4-Methylumbelliferyl α-L-Iduronic Acid-2-sulfate Sodium Salt; 4-Methyl-2-oxo-2H-1-benzopyran-7-yl α-L-Idopyranosiduronic Acid 2-(Hydrogen Sulfate) CAS No: 1045020-74-3 Molecular Formula: C₁₆H₁₄Na₂O₁₂S Molecular Weight: 476.32 Purity: ≥95% (HPLC) Appearance: White to off white powder Method for Determining Identity: Proton NMR and Mass Spectroscopic Analysis Elemental Analysis: As Reported Storage and Stability: May be stored at RT for short-term only. Long-term storage is recommended at -20°C. Stable for 6 months after receipt. Hygroscopic. Store under inert atmosphere