691614
anti-CD109, EBS-CD-046, mouse monoclonal antibody
Eine Lieferung in diese Region ist nicht möglich.
- SKU:
- 691614
- Zusätzliche Namen:
- CD109 antigen, 150 kDa TGF-beta-1-binding protein, C3 and PZP-like alpha-2-macroglobulin domain-containing protein 7, Platelet-specific Gov antigen, p180, r150, CD antigen CD109, CD109, CPAMD7
- Anwendung:
- Flow Cytometry, IHC, IF, ICC
- Konzentration:
- 100 ug/ml
- Aufreinigung:
- Affinity Purified
- Lagerbedingungen:
- Please refer to datasheet
- Hersteller:
- Progen
- Host:
- Mouse
- Reaktivitäten:
- Human
- ABP:
- No Import Docs
- Immunogen:
- Recombinant human CD109
- Formulierung:
- PBS with 0.02% sodium azide
- Klon:
- EBS-CD-046
- Uniprot:
- Q6YHK3
- Synonyme:
- 150 kDa TGF-beta-1-binding protein;activated T-cell marker CD109;C3 and PZP-like alpha-2-macroglobulin domain-containing protein 7;CD109 antigen;CPAMD7;Gov platelet alloantigens;p180;platelet-specific Gov antigen;r150
- Weitere Details:
- CD109 is a GPI-anchored member of the alpha-2-macroglobulin (A2M) and complement family of proteins. It is expressed on activated T-cells, platelets, hematopoietic stem cells, megakaryocyte precursors, vascular endothelial cells, basal and myoepithelial cells of secretory glands, and squamous cell carcinomas. A 170-180 kDa precursor is autocatalytically reduced to 150 kDa and 120 kDa forms. On keratinocytes CD109 binds TGF-beta and associates with TGF-beta RI and TGF-beta RII, resulting in inhibition of TGF-beta signalling. Polymorphisms of CD109 include the platelet-specific Gov antigen and the blood group ABH antigens. Alloantibodies directed against these antigens result in unsuccessful platelet transfusions, neonatal alloimmune thrombocytopenia, and post-transfusion purpura. Positive control: human platelets, blood vessels.
- Versandbedingungen:
- Blue Ice