691561
anti-CD11c, EBS-CD-011, mouse monoclonal antibody
Eine Lieferung in diese Region ist nicht möglich.
- SKU:
- 691561
- Zusätzliche Namen:
- Integrin alpha-X, CD11 antigen-like family member C, Leu M5, Leukocyte adhesion glycoprotein p150,95 alpha chain, Leukocyte adhesion receptor p150,95, CD antigen CD11c, ITGAX, CD11C
- Anwendung:
- Flow Cytometry, IHC, IF, ICC
- Konzentration:
- 100 ug/ml
- Aufreinigung:
- Affinity Purified
- Lagerbedingungen:
- Please refer to datasheet
- Hersteller:
- Progen
- Host:
- Mouse
- Reaktivitäten:
- Human
- ABP:
- No Import Docs
- Immunogen:
- Human macrophages
- Formulierung:
- PBS with 0.02% sodium azide
- Klon:
- EBS-CD-011
- Uniprot:
- P20702
- Synonyme:
- CD11 antigen-like family member C;CD11C;complement component 3 receptor 4 subunit;integrin alpha X;integrin alpha-X;integrin, alpha X (antigen CD11C (p150), alpha polypeptide);integrin, alpha X (complement component 3 receptor 4 subunit);Leu M5;leu M5, alpha subunit;leukocyte adhesion glycoprotein p150,95 alpha chain;leukocyte adhesion receptor p150,95;leukocyte surface antigen p150,95, alpha subunit;myeloid membrane antigen, alpha subunit;p150 95 integrin alpha chain;SLEB6
- Weitere Details:
- Integrin alpha-X (CD11c, leukocyte surface antigen p150/95, CR4, Axb2) is a type 1 transmembrane protein that traditionally combines with beta-2 chain to form a leukocyte-specific integrin known as inactivated-C3b (iC3b) receptor 4 (CR4). Integrin alpha-X/beta-2 shares similar properties of the integrin alpha-M/beta-2 in mediating adherence of neutrophils and monocytes to stimulated endothelial cells and in phagocytosis of complement coated particles. Abnormal expression of integrin alpha-X is characteristic of hairy cell leukemia (HCL) and is dependent upon activation of proto-oncogenes Ras and JunD. Integrin alpha-X is present on dendritic cells, macrophages and NK-cells. Upon activation, DCs present in skin (Langerhans cells, lining of nose, lung, stomach, intestine and blood can migrate to lymphoid tissues and interact with T- and B-cells to initiate and shape the immune response. Positive control: human dendritic cells. Human lymph node and tonsil.
- Versandbedingungen:
- Blue Ice