Iturin A-2, Antifungal Antitumor

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£650.00

SKU:: 15171
Lagerbedingungen:: -20[o]C
Hersteller:: Funakoshi
CAS Number:: 83785-07-3
Weitere Details:: M.W.: 1,043.190 Purity : >90％ (HPLC) Molecular Formula : C48H74N12O14 Solubility : Soluble in MeOH, DMSO, and DMF Insoluble in H2O. Iturin A-2 is a cyclic polypeptide with antifungal activity. It was reported that the bioactive compound showed suppression of damping-off disease of tomato (seedling disease) and cytotoxicity to human breast cancer cell line BT-474. Pharmacophore mapping studies suggested that the angiotensin-converting enzyme 2 (ACE2) as one of the potential targets of iturin A-2. This finding indicates that these lipopeptides may bind to SARS-CoV-2 nsp12 (RNA-dependent RNA polymerase) efficiently.