10-5705
SU9516
Größe
£173.00
- SKU:
- 10-5705
- Physischer Zustand:
- Solid
- Molekulargewicht:
- 241.25
- Reinheit:
- >98%
- Aufreinigung:
- HPLC Purified
- Lagerbedingungen:
- -20[o]C
- Hersteller:
- Focus Biomolecules
- CAS Number:
- 377090-84-1
- Immunogen:
- Kinase
- Weitere Details:
- Cyclin-dependent kinase inhibitor, IC50s= 0.02-0.03, 0.04-0.2, 0.2-1.7 and 0.9 uM for cdk2, cdk1, cdk4, cdk9 respectively.1,2 Inhibits phosphorylation of retinoblastoma protein pRb, causing enhanced pRb/E2f complex formation, cell cycle arrest at G1 and G2-M and apoptosis.3 Down-regulates antiapoptotic protein Mcl-1 expression resulting in mitochondrial injury and cell death.4 Inhibits epithelial-mesenchymal transition (IC50=1.21 uM) a crucial pathological event in tumor cell budding and metastasis.5 Cell permeable.
- Versandbedingungen:
- Ambient