10-5688
BMH-21
Größe
£151.00
- SKU:
- 10-5688
- Physischer Zustand:
- Solid
- Molekulargewicht:
- 360.42
- Reinheit:
- >98%
- Aufreinigung:
- HPLC Purified
- Lagerbedingungen:
- -20[o]C
- Hersteller:
- Focus Biomolecules
- CAS Number:
- 896705-16-1
- ABP:
- No Import Docs
- Immunogen:
- DNA|RNA|Transcription factor
- Weitere Details:
- A planar heterocyclic DNA intercalator that inhibits RNA polymerase I (Pol I), IC50 = 0.6 uM in U2OS cells, but not Pols II or III, blocking transcription elongation without inducing the DNA damage response.1-3 Inhibition disengages Pol I from chromatin, resulting in proteasome-dependent destruction of Pol I subunit RPA194.4 At nanomolar concentrations it also activates p53 in A375 cells.5
- Versandbedingungen:
- Ambient