10074-G5

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£153.00

SKU:: 10-5627
Physischer Zustand:: Solid
Molekulargewicht:: 332.32
Reinheit:: 98%
Lagerbedingungen:: -20[o]C
Hersteller:: Focus Biomolecules
CAS Number:: 413611-93-5
Immunogen:: Transcription factor
Weitere Details:: Inhibits c-Myc by disrupting c-Myc/Max heterodimer formation and inhibiting its transcriptional activity.1 10074-G5 binds to the c-Myc bHLHZip domain with Kd=2.8 mM.1 It was cytotoxic in C-Myc-overexpressing cell lines (IC50s = 13 to 15 mM) but was not active in vivo due to rapid metabolism.2 10074-G5 is a useful tool to probe for involvement of c-Myc involvement in cellular processes.3,4 Binds to and sequesters the intrinsically disordered amyloid-B Beta (AB Beta) in its monomeric soluble state and rescues a C. elegans model of AB Beta-associated toxicity.5