10-5521
GW788388
Größe
£177.00
- SKU:
- 10-5521
- Physischer Zustand:
- Solid
- Molekulargewicht:
- 425.49
- Reinheit:
- 98%
- Aufreinigung:
- HPLC Purified
- Lagerbedingungen:
- -20[o]C
- Hersteller:
- Focus Biomolecules
- CAS Number:
- 452342-67-5
- Immunogen:
- Kinase
- Weitere Details:
- Potent inhibitor of TGF-B Beta receptor kinases ALK4, ALK5 (IC50=18 nM), ALK7, and TGFB BetaRII, but not BMP type II receptor kinase.1,2 Blocks TGF-B Beta-mediated signaling, including collagen type I and VEGF, in turn reducing fibrosis and angiogenesis in various mouse models.3,4 GW788388 attenuates TGF-B Beta-induced epithelial to mesenchymal transition (EMT) in human peritoneal mesothelial cells.5
- Versandbedingungen:
- Ambient