AR7

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£168.00

SKU:: 10-5515
Physischer Zustand:: Solid
Molekulargewicht:: 257.72
Reinheit:: 98%
Lagerbedingungen:: -20[o]C
Hersteller:: Focus Biomolecules
CAS Number:: 80306-38-3
Immunogen:: Retinoid receptor and related|Transcription factor
Weitere Details:: Atypical retinoid which acts as an RARA Alpha antagonist and activates chaperone-mediated autophagy (CMA) via an RAR-dependent pathway.1 Downstream signaling results in an increase of LAMP-2A expression.1 Cells pretreated with AR7 had markedly improved viability in a paraquat-induced oxidative stress model.1 AR7 stimulated CMA and attenuated accumulation of SNCA oligomers in prolonged cultures of mutant cortical neurons2 indicating that CMA activation may be a viable disease modifying strategy in Parkinson's disease3. A targetome analysis of AR7-induced CMA in cancer cells has been performed.4