10-5449
CDDO-Me
Größe
£158.00
- SKU:
- 10-5449
- Zusätzliche Namen:
- Bardoxolone methyl|CDDO-Methyl ester|RTA 402|TP-155
- Physischer Zustand:
- Solid
- Molekulargewicht:
- 505.7
- Reinheit:
- >98%
- Aufreinigung:
- HPLC Purified
- Lagerbedingungen:
- -20[o]C
- Hersteller:
- Focus Biomolecules
- CAS Number:
- 218600-53-4
- Immunogen:
- Kinase|Transcription factor
- Weitere Details:
- Potent activator of Nrf2 target transcription via interaction with thiol groups of Keap1, an Nrf2 partner, in phase 2 response against oxidative stress.1 Inhibits the NF-K KappaB pathway via inhibition of IKKA Alpha activation in vitro2 and reduces expression of proinflammatory cytokines in vivo3. Alters tumor microenvironment causing breast tumor associated macrophages to switch from tumor-promoting to tumor-inhibiting characteristics in vitro.4 Reduces cancer stem cell marker expression in Ec109 and KYSE70 cells.5
- Versandbedingungen:
- Ambient