10-5332
MLS-544460
Größe
£158.00
- SKU:
- 10-5332
- Zusätzliche Namen:
- MLS000544460
- Physischer Zustand:
- Cream/off-white solid
- Molekulargewicht:
- 341.36
- Reinheit:
- >98%
- Lagerbedingungen:
- -20[o]C
- Hersteller:
- Focus Biomolecules
- CAS Number:
- 352336-36-8
- Immunogen:
- Phosphatase
- Weitere Details:
- MLS-544460 is an allosteric inhibitor of the Eya2 tyrosine phosphatase (IC50=4.1 uM)1-2 which is ineffective against other tyrosine phosphatases including Eya3 and PTP1B. Treatment of patient-derived glioma stem cells induced loss of bipolar spindle formation along with G2/M cell cycle arrest. GSC proliferation was inhibited at concentrations 4 to 10-fold lower than normal brain cells.3 Treatment of Axolotls following amputation impairs limb regeneration indicating a role for Eya2 in vertebrate regeneration.4
- Versandbedingungen:
- Ambient