10-5056
ICRF-193
Größe
£221.00
- SKU:
- 10-5056
- Physischer Zustand:
- Solid
- Molekulargewicht:
- 282.3
- Reinheit:
- >98%
- Lagerbedingungen:
- -20[o]C
- Hersteller:
- Focus Biomolecules
- CAS Number:
- 21416-88-6
- Immunogen:
- DNA|Topoisomerase
- Weitere Details:
- ICRF-193 is a topoisomerase II poison.1 Toposiomerase poisons are a special subclass of topoisomerase inhibitors that stabilize topoisomerase-DNA strand passing intermediates and thus cause the topoisomerases to become a cytotoxic DNA-damaging agent.1 It readily induces DNA strand breaks in V79 and irs-2 Chinese hamster lung fibroblasts via a novel mechanism.2 Displays cardioprotective (against anthracycline toxicity)3 and anti-inflammatory effects via reduction of IL-1B Beta secretion by macrophages4. An important tool for studying the cellular response to DNA double-strand breaks.5
- Versandbedingungen:
- Ambient