10-4989
EW-7197
Größe
£158.00
- SKU:
- 10-4989
- Zusätzliche Namen:
- Vactosertib
- Physischer Zustand:
- Solid
- Molekulargewicht:
- 399.43
- Reinheit:
- >98%
- Aufreinigung:
- HPLC Purified
- Lagerbedingungen:
- -20[o]C
- Hersteller:
- Focus Biomolecules
- CAS Number:
- 1352608-82-2
- Immunogen:
- Kinase
- Weitere Details:
- EW-7197 is a potent (IC50 = 13 nM ALK4, 11 nM ALK5 HotSpot assay) and selective inhibitor of ALK4/5.1 It increased CD3+, IFN+CD8+, and NK cells and decreased myeloid suppressor cells in a mouse model of osteosarcoma.2 EW-7197 suppressed the epithelial-mesenchymal transition in various cancer models.3-5 It synergized with pomalidomide to increase T-cell fitness in a multiple myeloma model.6 EW-7197 displayed therapeutic effects in various models of fibrosis.7,8
- Versandbedingungen:
- Ambient