ML792

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£192.00

SKU:: 10-4985
Physischer Zustand:: Solid
Molekulargewicht:: 551.42
Reinheit:: >98%
Aufreinigung:: HPLC Purified
Lagerbedingungen:: -20[o]C
Hersteller:: Focus Biomolecules
CAS Number:: 1644342-14-2
Immunogen:: Ubiquitin ligase
Weitere Details:: ML792 is a potent (IC50's = 3 nM SUMO1; 11 nM SUMO2) and selective( IC50 = 32 uM for NEDD8-activating enzyme (NAE)) mechanism-based inhibitor of SUMO-activating enzyme (SAE).1 Treatment of multiple cancer cell lines led to failure of mitotic progression and induction of endoreduplication with MYC-amplified cell lines showing higher sensitivity. ML792 inhibited B-cell growth and promoted cell death in Epstein-Barr virus (EBV)-positive B cells and nasopharyngeal carcinoma cells. It also modulated Latent Membrane Protein-1-induced cell migration and cell adhesion suggesting therapeutic potential in treating EBV-associated malignancies.2