10-4957
Olodanrigan
Größe
£173.00
- SKU:
- 10-4957
- Zusätzliche Namen:
- EMA401
- Physischer Zustand:
- Solid
- Molekulargewicht:
- 507.59
- Reinheit:
- >98%
- Aufreinigung:
- HPLC Purified
- Lagerbedingungen:
- -20[o]C
- Hersteller:
- Focus Biomolecules
- CAS Number:
- 1316755-16-4
- Immunogen:
- GPCR
- Weitere Details:
- Potent (IC50 = 39.5 nM) and selective (>10,000-fold selectivity AT2R/AT1R) antagonist of the angiotensin II type 2 receptor.1 It produced dose-dependent relief of hindpaw sensitivity in a rat model of neuropathic pain1 and showed efficacy in a human trial against postherpetic neuralgia2. Olodanrigan prevented paclitaxel-associated acute pain syndrome in mice.3 It blocked visceral hypersensitivity and colonic hyperpermeability in a rat model of irritable bowel syndrome.4 It was also able to inhibit proliferation of AT2R-expressing glioblastoma spheroids and blocked their invasiveness and angiogenic capability.5
- Versandbedingungen:
- Ambient