10-4920
Motolimod
Größe
£177.00
- SKU:
- 10-4920
- Zusätzliche Namen:
- VTX-2337
- Physischer Zustand:
- Solid
- Molekulargewicht:
- 458.61
- Reinheit:
- 98%
- Aufreinigung:
- HPLC Purified
- Lagerbedingungen:
- -20[o]C
- Hersteller:
- Focus Biomolecules
- CAS Number:
- 926927-61-9
- Immunogen:
- Inflammasome|TLR (Toll-like receptor)
- Weitere Details:
- Motolimod (926927-61-9) is a selective Toll-like receptor 8 (TLR8) agonist (EC50 = 100 nM). It stimulates the production of TNFA Alpha and IL-12 from monocytes and myeloid dendritic cells. Motolimod also stimulated IFNG Gamma production from NK cells and increased their toxicity against K562 and ADCC by rituximab and trastuzumab.1,2 It induced apoptosis in monocytic myeloid-derived suppressor cells.3 Motolimod is being investigated in combination with other cancer immunotherapies.4,5 Motolimod has also been shown in induce secreted IL-1b and IL-8 via activation of the NLRP3 inflammasome.6
- Versandbedingungen:
- Ambient