10-4908
I2
Größe
£173.00
- SKU:
- 10-4908
- Physischer Zustand:
- Orange/red solid
- Molekulargewicht:
- 451.23
- Reinheit:
- 98%
- Lagerbedingungen:
- -20[o]C
- Hersteller:
- Focus Biomolecules
- CAS Number:
- Unknown
- ABP:
- No Import Docs
- Immunogen:
- UPR (Unfolded protein response)
- Weitere Details:
- I2 is an inhibitor of the oxidoreductase ERO1A (IC50 = 8.1 uM), a mediator of the unfolded protein response (UPR).1 Under cancer-related hypoxia conditions, ERO1A favors the folding of the angiogenic protein VEGFA leading to cancer cell growth and spread. I2 inhibited the metabolic activity of DMA-MB-231 triple negative breast cancer cells and impaired migration and VEGF secretion. Tumors in C57/BL6Jmice showed decreased levels of VEGF and PD-L1 when treated with I2.
- Versandbedingungen:
- Ambient