10-4903
BMS-1166
Größe
£163.00
- SKU:
- 10-4903
- Physischer Zustand:
- Solid
- Molekulargewicht:
- 641.12
- Reinheit:
- >98%
- Aufreinigung:
- HPLC Purified
- Lagerbedingungen:
- -20[o]C
- Hersteller:
- Focus Biomolecules
- CAS Number:
- 1818314-88-3
- Immunogen:
- PD-1
- Weitere Details:
- BMS-1166 blocks the cell surface interaction of PD-L1 with PD-1 alleviating the inhibitory effect of PD-L1 on T-cell receptor-mediated activation of T-lymphocytes (IC50 = 1.4 nM).1,2 It suppressed growth and invasion of glioma cells3 and induced apoptosis in conjunction with the dual PI3K/mTOR inhibitor BEZ2354. BMS-1166 reversed HEL-mediated T cell suppression in acute myeloid leukemia patients.5 It significantly decreased cell viability and enhanced chemotherapy-induced cytotoxicity in MDF-MB-231 and MCF-7 breast cancer models.6
- Versandbedingungen:
- Ambient