10-4892
Methylbenzoprim
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£168.00
- SKU:
- 10-4892
- Zusätzliche Namen:
- Compound 19-S|MBP|NSC382035
- Physischer Zustand:
- Red/Orange solid
- Molekulargewicht:
- 378.44
- Reinheit:
- >98%
- Aufreinigung:
- HPLC Purified
- Lagerbedingungen:
- -20[o]C
- Hersteller:
- Focus Biomolecules
- CAS Number:
- 118344-71-1
- Immunogen:
- DHFR (Dihydrofolate reductase)|DNA
- Weitere Details:
- Methylbenzoprim, a derivative of the antimalarial drug Pyrimethamine, is a non-classical potent inhibitor of mammalian dihydrofolate reductase (IC50 = 3.2 nM rat liver).1 It inhibited melanoma tumor growth both in vitro and in vivo.2 Methylbenzoprim has been recently found to also inhibit thymidylate synthase (TYMS) with activity comparable to the 5-FU metabolite FdUrd.3 It was more potent than 5-fluorouracil in a panel of 4 pancreatic ductal adenocarcinoma cells lines and without TYMS overexpression that frequently leads to drug resistance.3 Methylbenzoprim inhibited tumor growth and progression in two pancreatic cancer xenograft models. Orally bioavailable.
- Versandbedingungen:
- Ambient