10-4831
WP1066
Größe
£177.00
- SKU:
- 10-4831
- Physischer Zustand:
- Solid
- Molekulargewicht:
- 356.22
- Reinheit:
- 98%
- Aufreinigung:
- HPLC Purified
- Lagerbedingungen:
- -20[o]C
- Hersteller:
- Focus Biomolecules
- CAS Number:
- 857064-38-1
- Immunogen:
- Kinase|Transcription factor
- Weitere Details:
- WP1066 (857064-38-1) is an inhibitor of the JAK2/STAT3 pathway as well as STAT5 and AKT.1,2,3 It downregulated Bcl-XL, Mcl-1, and c-myc while activating Bax and inducing apoptosis.1 Active against human malignant glioma U87-MG (IC50 = 5.6uM) and U373-MG (IC50 = 3.7uM) cells. Enhances T-cell cytotoxicity via inhibition of regulatory T-cells.4,5 WP1066 abrogated PD-L1 expression in lymphoma cell lines.6
- Versandbedingungen:
- Ambient